Nicotine Uptake and Abuse Liability Assessments of Blu Disposable Electronic Cigarettes

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

This study assesses the nicotine uptake, abuse liability and puffing topography of blu disposable e-cigarettes in adult combustible cigarette smokers. Nicotine uptake, subjective effects, and puff topography are evaluated and compared with subjects' usual brand combustible cigarette.

Key facts

Study ID

NCT05457634

Run by

Fontem US LLC

People needed

20

Starts

2021-07-13

Expected to finish

2024-08-31

Last updated by the study team

2025-09-17

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects must be current smokers (≥10 per day) of combustible cigarettes for at least 6 continuous months before Visit 1 and may be occasional users of e-cigarettes
• Subjects have urine cotinine >200 ng/mL and exhaled carbon monoxide > 10 ppm at Screening
• Subject has a seated systolic blood pressure ≤160 mmHg, diastolic blood pressure
• ≤95 mmHg, and heart rate ≤100 bpm
• Females of childbearing potential who are practicing a reliable method of contraception

You may not qualify if…

• Subjects who have used any nicotine or tobacco product other than e-cigarettes or combustible cigarettes in the 14 days prior to Visit 1
• Subjects who have an acute illness requiring treatment in the 4 weeks prior to Visit 1
• Subjects with clinically significant and relevant abnormalities of medical history.
• Subjects who have used any prescription or over-the-counter smoking cessation treatments within 30 days prior to Visit 1
• Pregnant or breastfeeding female subjects

Where it is running

• LA Clinical Trials, LLC — Burbank, California, United States

Full record on ClinicalTrials.gov

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