Obstructive Sleep Apnea Treatment in Serious Mental Illness

Starting soon · Not applicable

Conditions studied: Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Obstructive Sleep Apnea of Adult

In brief

Serious mental illnesses (SMI) like schizophrenia and bipolar disorder are two of the most disabling and costly chronic illnesses worldwide. A high proportion of adults with schizophrenia and bipolar disorder have sleep disorders, like obstructive sleep apnea (OSA), but tend to be underdiagnosed and undertreated compared to the general population. This study aims to examine feasibility, acceptance, and impact of OSA treatment and how it affects cognitive function in people with SMI.

Key facts

Study ID

NCT05457127

Run by

University of California, San Diego

People needed

300

Starts

2025-01-01

Expected to finish

2026-11-01

Last updated by the study team

2024-07-10

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Control participants:
• lifetime absence of major psychiatric illness
• 40 to 70 years old
• be at risk for or have a diagnosis of obstructive sleep apnea
• For participants with serious mental illness:
• diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder
• must not be conservatized
• 40 - 70 years old
• be at risk or have a diagnosis of obstructive sleep apnea.

You may not qualify if…

• DSM-IV-TR diagnosis of active alcohol or other substance abuse or dependence in the 3 months preceding enrollment. This will be self-report.
• Diagnosis of dementia, mental retardation, or other neurological or medical conditions known to affect neurophysiologic or neurocognitive functioning, or autoimmune disease
• Other major DSM-IV-TR Axis I Disorder
• Medical problems that interfere with a participant's ability to complete the assessments
• Plans to move out of the San Diego county area within the following 6 months
• Diagnosis of OSA and currently receiving APAP, CPAP, or any treatment from a physician.

Where it is running

• UCSD — La Jolla, California, United States

Full record on ClinicalTrials.gov

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