BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Sickle Cell Disease
In brief
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Key facts
- Study ID
- NCT05456880
- Run by
- Beam Therapeutics Inc.
- People needed
- 15
- Starts
- 2022-08-30
- Expected to finish
- 2028-02-01
- Last updated by the study team
- 2025-12-16
Who can join
Age: 12 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Mayo Clinic Florida — Jacksonville, Florida, United States
- University of Miami — Miami, Florida, United States
- Children's Healthcare of Atlanta - Aflac Cancer and Blood Disorders Center - Egleston Hospital — Atlanta, Georgia, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- Henry Ford Cancer Center — Detroit, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Washington University School of Medicine in St. Louis — St Louis, Missouri, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- Columbia University Irving Medical Center — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- The Cleveland Clinic Foundation — Cleveland, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Medical University of South Carolina — Charleston, South Carolina, United States
- St Jude Children's Research Hospital — Memphis, Tennessee, United States
- The Children's Hospital at TriStar Centennial — Nashville, Tennessee, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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