A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

Running, not enrolling · Phase 3

Conditions studied: Pterygium

In brief

The objective is to evaluate the safety and efficacy of low dose and high dose CBT-001 eye drop dosed twice daily for 24 months compared to vehicle in reducing conjunctival hyperemia and preventing pterygium progression in eyes with pterygia.

Key facts

Study ID

NCT05456425

Run by

Cloudbreak Therapeutics, LLC

People needed

660

Starts

2022-06-30

Expected to finish

2027-12-31

Last updated by the study team

2025-09-24

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pterygium with conjunctival hyperemia

You may not qualify if…

• Pterygium removal within the last 6 months

Where it is running

• Trinity Research Group — Dothan, Alabama, United States
• Horizon Eye Specialists & LASIK Center — Sun City, Arizona, United States
• West Coast Eye Institute — Bakersfield, California, United States
• Global Research Mangement — Glendale, California, United States
• Inland Eye Specialists — Hemet, California, United States
• Eye Research Foundation — Newport Beach, California, United States
• Shultz Chang Vision — Northridge, California, United States
• North Bay Eye Associates INC — Petaluma, California, United States
• Santa Barbara Eye Care — Santa Barbara, California, United States
• Advanced Research; LLC — Deerfield Beach, Florida, United States
• Bruce A. Segal, MD — Delray Beach, Florida, United States
• International Research Center — Tampa, Florida, United States
• The Eye Care Institute — Louisville, Kentucky, United States
• Center for Sight — Henderson, Nevada, United States
• Vance Thompson Vision — Sioux Falls, South Dakota, United States
• Baylor College of Medicine — Houston, Texas, United States
• DCT-Shah Research, LLC dba Discovery Clinical Trials — McAllen, Texas, United States
• Clinical Trials of Texas — San Antonio, Texas, United States
• R and R Eye Research — San Antonio, Texas, United States
• Emerson Clinical Research Institute, LLC — Falls Church, Virginia, United States
• The Centre for Eye Research Australia — East Melbourne, Melbourne, Australia
• Eyeclinic Albury Wodonga — Albury, New South Wales, Australia
• Sydney Eye Hospital — Sydney, New South Wales, Australia
• Bendigo Eye Clinic — Bendigo, Victoria, Australia
• Sunshine Eye Surgeons — St Albans, Victoria, Australia

Full record on ClinicalTrials.gov

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