Topical Cannabidiol Application and Skin Vascular Reactivity

Withdrawn before enrolling · Not applicable · Has a placebo group

Conditions studied: Effect of Drug

In brief

Cannabidiol, or CBD, is an over-the-counter "nutraceutical" that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.

Key facts

Study ID

NCT05456113

Run by

Penn State University

People needed

0

Starts

2024-12-01

Expected to finish

2026-10-01

Last updated by the study team

2025-01-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women 18 years of age and older
• English speaking
• Non-obese class III, BMI ≤ 39.9
• Normal HbA1C of <6.5%

You may not qualify if…

• Abnormal resting heart rate (<60 or >100 bpm) or BP (systolic <100 or >129 mmHg, diastolic <60 or >100 mmHg) values
• Rash, skin disease, disorders of pigmentation
• Known skin allergies
• Diabetes
• Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
• Illegal drug use
• Recent (within the last 30 days) CBD users either topical or oral
• Allergy or hypersensitivity to investigational agents
• Women who are pregnant or breastfeeding

Where it is running

• Noll Laboratory — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

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