CBT Enhanced With Social Cognitive Training vs. CBT Only With Depressed Youth

Recruiting now · Not applicable

Conditions studied: Depression

In brief

Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to either an enhanced CBT intervention that teaches social cognitive skills, particularly social perspective taking and theory of mind (CBTSCT) as compared to CBT only. The primary target is improvement in both social cognitive skills and depressive symptoms at post-treatment and at a 6-month follow-up.

Key facts

Study ID

NCT05456035

Run by

Vanderbilt University

People needed

82

Starts

2022-10-10

Expected to finish

2026-08-01

Last updated by the study team

2025-09-09

Who can join

Age: 13 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants ages 13- through 17-years-old
• Youth must have a diagnosis of a current depressive disorder (e.g., major depressive episode; persistent depressive disorder) or a score on the Patient Health Questionnaire (PHQ9) > 15

You may not qualify if…

• ever met criteria for a diagnosis of bipolar disorder, schizophrenia, autism, or conduct disorder
• current alcohol or substance use disorder with significant impairment
• imminent risk of suicide
• reading level < 4th grade

Where it is running

• Judy Garber — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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