Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles

Recruiting now · Not applicable

Conditions studied: Memory, Delayed

In brief

The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by application of auditory and electrical stimulations during sleep and its effect on modulating memory processes.

Key facts

Study ID

NCT05452122

Run by

University of California, Los Angeles

People needed

150

Starts

2022-07-13

Expected to finish

2026-08-31

Last updated by the study team

2025-10-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All epilepsy patients between the ages of 18 and 65 who undergo depth electrode placement for clinical purposes
• Eligibility is determined by the epilepsy surgery team (based on neuropsychological testing and on psychiatric evaluation)
• Willing to provide informed consent and participate the study

You may not qualify if…

• Neurological or psychiatric issues, other than epilepsy, that would put the patient at risk
• Patient is younger than 18 or older than 65 years of age
• Unwilling to provide informed consent

Where it is running

• University of California Los Angeles — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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