A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis

Recruiting now

Conditions studied: Radiation Pneumonitis

In brief

Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy. The purpose of this study is to: * Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis. * Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy. * Construct a predictive model for radiation pneumonitis. * Evaluate survival and treatment outcome of patients with radiation pneumonitis.

Key facts

Study ID

NCT05448703

Run by

Huazhong University of Science and Technology

People needed

300

Starts

2021-02-25

Expected to finish

2026-09-01

Last updated by the study team

2022-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of lung cancer by histology
• Radiation dose at least 45 Gy
• Karnofsky >60
• Age>18
• Life expectancy of at least 6 months

You may not qualify if…

• Previous thoracic irradiation
• Severe cardiopulmonary diseases

Where it is running

• Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• Jingjiang People' Hospital — Jingjiang, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.