GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries

Enrolling by invitation · Phase 3

Conditions studied: Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy

In brief

The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery. Spinal anesthesia in decompressive procedures can be the new standard of care. Recently, it has been found that regional analgesia is option that has been shown to improve pain and opioid-related outcomes after spine surgery, but has not yet been studied in combination with spinal anesthesia. This is study that consists of two groups: standard of care general anesthesia with a nerve block and a spinal anesthesia with nerve block. Patients are randomized to either of the two groups. There will be 71 patients enrolled in each group for this study.

Key facts

Study ID: NCT05444751
Run by: Hospital for Special Surgery, New York
People needed: 142
Starts: 2022-03-22
Expected to finish: 2026-09-01
Last updated by the study team: 2026-04-28

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients from the ages 18- 80 years
Patients with one or two-level microdiscectomy, laminotomy, or foraminotomy - prior spine surgery is allowed only if surgery was preformed at other levels.
Able to follow study protocol
Able to provide informed consent

You may not qualify if…

Surgery with planned need for postoperative surgical drain.
Allergies of contraindication to any study anesthetic or analgesic medications.
Morbid obesity, defined as BMI > 35 kg/m2.
Involved in the study of another investigational product that may affect the outcome.

Where it is running

Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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