Genomic Predictors of Recurrent Pregnancy Loss

Recruiting now

Conditions studied: Recurrent Pregnancy Loss

In brief

The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.

Key facts

Study ID

NCT05444283

Run by

Yale University

People needed

500

Starts

2021-09-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women with loss of a current singleton pregnancy at < 20 0/7 weeks gestation, documented by ultrasonography or histopathological examination
• History of one or more prior pregnancy losses
• Euploid current pregnancy confirmed by karyotype, microarray, or STORK (Short-read Transpore Rapid Karyotyping) sequencing Note: A limited number of aneuploid losses will be included as part of the pilot phase

You may not qualify if…

• History of parental karyotype abnormalities
• History of antiphospholipid antibody syndrome
• Evidence of uncontrolled diabetes
• Evidence of uncontrolled thyroid disease
• History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis)
• History of uterine anomalies
• History of cervical insufficiency
• Cohort B - Maternal Effect Gene Cohort
• Inclusion Criteria:
• Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child
• Exclusion Criteria:
• Known etiology for pregnancy loss

Where it is running

• University of Texas at San Antonio — San Antonio, Texas, United States (enrolling)
• Yale University — New Haven, Connecticut, United States (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• University of Colorado — Aurora, Colorado, United States (enrolling)
• Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
• Wayne State University — Detroit, Michigan, United States (enrolling)
• Columbia University — New York, New York, United States (enrolling)
• Pennsylvania State University — Hershey, Pennsylvania, United States (enrolling)
• University of Texas at Austin — Austin, Texas, United States (enrolling)
• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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