Home Exercise for Individuals with Neurodegenerative Disease

Recruiting now · Not applicable

Conditions studied: Neurodegenerative Diseases, Leukodystrophy, Ataxia, LBSL, Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder), Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation, Cerebellar Ataxia, Adrenomyeloneuropathy

In brief

The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.

Key facts

Study ID

NCT05443906

Run by

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

People needed

30

Starts

2023-02-13

Expected to finish

2027-07-30

Last updated by the study team

2025-03-10

Who can join

Age: 5 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.
• The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.
• The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.
• For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.
• We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam.
• Healthy Volunteers
• Able to stand for 30 seconds without upper extremity support
• Ambulatory (including use of a cane or a walker)
• Able to walk for 2 minutes

You may not qualify if…

• Other medical or psychological conditions which in the clinical judgement of the investigator would interfere with acquiring the study information or performing the exercises safely including but not limited to:
• Uncontrolled hypertension, orthopedic conditions, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy

Where it is running

• Kennedy Krieger Institute — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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