Disease Activity Biomarkers in Patients With Systemic Lupus Erythematosus

Recruiting now

Conditions studied: Lupus Nephritis

In brief

The aim of this research project is to better understand the origin and clinical significance of two lupus-specific "genetic signatures" (IFN signature and plasma cell signature) in patient subgroups with well-defined clinical characteristics. Our aim is to correlate these genetic signatures with cell activation profiles and the production of specific cytokines in different populations from whole blood and in short-term cultures of these circulating cells.

Key facts

Study ID

NCT05443516

Run by

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

People needed

250

Starts

2014-06-16

Expected to finish

2032-12-31

Last updated by the study team

2022-07-05

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Fulfilment of the EULAR/ACR classification criteria of SLE.
• 18 years of age or above.
• Incident or Flare biopsy-proven proliferative or membranous LN

You may not qualify if…

• Antiphospholipid syndrome nephropathy (APSN).
• Pregnancy at baseline (pregnancy during follow-up will not lead to exclusion).
• Anticipated non-adherence to therapy.
• Medical conditions interfering with outcome evaluations.
• Inability to read and/or sign the informed consent form.

Where it is running

• Cliniques universitaires Saint-Luc — Brussels, Belgium (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.