Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture

Recruiting now · Phase 4

Conditions studied: Dupuytren Contracture, Dupuytren's Disease, Contracture, Joint Diseases, Musculoskeletal Diseases, Fibroma, Neoplasm, Fibrous Tissue, Neoplasms, Connective Tissue, Neoplasms, Connective and Soft Tissue, Neoplasms by Histologic Type, Neoplasms, Connective Tissue Diseases

In brief

Comparing percutaneous needle fasciotomy +/- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.

Key facts

Study ID: NCT05440240
Run by: Regionshospitalet Silkeborg
People needed: 400
Starts: 2023-01-10
Expected to finish: 2030-03-01
Last updated by the study team: 2023-05-17

Who can join

Age: 45 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Dupuytren contracture (DC) of ≥ 20° PED in MCP joint measured with a goniometer
DC of either II-V finger
Well-defined/palpable cord

You may not qualify if…

Legally incapacitated
Previous study inclusion with another finger ray
Isolated proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint contracture, defined as MCP joint contracture < 20° PED regardless of the deficit in the PIP or DIP joint
Previous hand surgery of the affected finger for any reason
Known allergy to the study medication
Anticoagulant therapy (Acetylsalicylic acid is NOT an exclusion criterion)
Pregnant or lactation
Insulin dependent diabetes mellitus
Ongoing systemic infection or local infection at the site of the procedure
Rheumatoid arthritis
Amyloidosis or mucopolysaccharidosis
Unable to communicate, cooperate or participate in follow-up

Where it is running

Silkeborg Regional Hospital — Silkeborg, Denmark (enrolling)

Full record on ClinicalTrials.gov

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