Acute Recording of Stereotyped High-Frequency Oscillations

Running, not enrolling · Not applicable

Conditions studied: Epilepsy

In brief

Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.

Key facts

Study ID

NCT05439655

Run by

Mayo Clinic

People needed

12

Starts

2021-09-01

Expected to finish

2026-08-11

Last updated by the study team

2026-07-20

Who can join

Age: 3 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with medically refractory epilepsy, who have been deemed appropriate candidates for intracranial EEG monitoring
• Adult men and women (18≤ age <70 years)
• children (3≤ age <18 years)
• includes women and minorities

You may not qualify if…

• Subjects will be excluded if their condition makes them unable to continue with recordings.

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States
• Baylor College of Medicine — Houston, Texas, United States

Full record on ClinicalTrials.gov

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