Impact of Cottonseed Oil on Oxidative Stress, Inflammation, and Metabolism

Completed · Not applicable

Conditions studied: Inflammation, Healthy, Oxidative Stress, Metabolic Syndrome

In brief

Recent research evidence suggests that cottonseed oil (CSO) may have both direct and indirect anti-inflammatory and anti-oxidative impacts linked to bioactive components of CSO and favorable alterations in lipid metabolism. These impacts are directly related to non-communicable diseases such as diabetes, cardiovascular diseases, and cancer. Our overarching hypothesis is that the effect of CSO consumption on oxidative stress markers (isoprostanes), inflammatory cytokines, metabolic biomarkers, and bile acid metabolism will be beneficial for reversing disease pathophysiology linked to oxidative stress, inflammation, and bile acids. Our long-term goal is to establish effective and practical therapeutic strategies utilizing dietary incorporation of CSO to prevent or reverse these diseases. The following hypotheses will be tested in the proposed investigation: H1: CSO consumption will lower exercise-induced oxidative stress, and the effect of CSO will be greater than that of OO for lowering of exercise-induced oxidative stress. H2: CSO consumption will lower inflammatory cytokines and metabolic markers linked to the inflammation process in human participants, and the effect of CSO will be greater than that of OO for lowering inflammation. H3: Features of serum bile acids, serum metabolomes, and lipidomes distinguishing CSO and OO treatment correspond to metabolic pathways illuminating the health benefits of CSO treatment. H4: Metabolic and inflammatory impacts of dietary oils will be greater for 60 g/d of CSO compared to 30 g/d.

Key facts

Study ID

NCT05439590

Run by

Montana State University

People needed

47

Starts

2022-08-08

Expected to finish

2023-11-03

Last updated by the study team

2023-11-18

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• are between the ages of 18-55 years
• have body mass index between 18-27 kg/m2

You may not qualify if…

• take medications to lower cholesterol, lipids, and/or inflammation,
• take blood pressure medications,
• take antioxidant supplements (Vitamin E or C or iron) at levels greater than 800 IU/day,
• have diabetes, a gallbladder condition, or have had gallbladder removed,
• take oral contraceptives regularly,
• have smoked in the past 30 days,
• consume alcohol more than 14 drinks/week,
• have an allergy to dairy, egg, tree nuts, peanuts, shellfish, soy, fish, wheat, legumes, extra virgin olive oil, and cottonseed oil, or have been on a ketogenic or paleo diet in the past six weeks,
• pregnant or lactating,
• on weight loss diet or planning to change exercise regimen,
• have physical mobility issues or are not able to walk on a treadmill,
• or have other health concerns or conditions that may interfere with your participation in the study

Where it is running

• Nutrition Research Laboratory — Bozeman, Montana, United States

Full record on ClinicalTrials.gov

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