A Trial to Compare Efficacy and Tolerability of Plenvu® and Picoprep® as Cleansing Agents Before Colonoscopy

Recruiting now · Phase 4

Conditions studied: Colon Disease

In brief

The trial is about comparing the efficacy of Plenvu with Picoprep. Both are bowel cleansing agents prior to visual examination of the large bowel to exclude cancer disease. 400 patients who are referred for colonoscopy to a single center in North Jutland will be randomised either to Picoprep or Plenvu. These patients will then answer a questionnaire prior to colonoscopy. The questionnaire is about the most common expected side effects and the experience of cleansing og intake of the bowel agents. The effect of the two agents will examined using a special scoring system (Harefield) to determine the quality of bowel cleansing. Colonoscopist who evaluate the cleansing is blinded to which agent the patient has taken.

Key facts

Study ID

NCT05436054

Run by

Aalborg University Hospital

People needed

400

Starts

2022-10-01

Expected to finish

2025-12-01

Last updated by the study team

2024-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ambulant colonoscopy
• Older than18

You may not qualify if…

• Younger than 18
• Known with severe heart failure
• Known with severe renal failure (eGFR<30)
• Known for colonic stenosis
• Pregnant or breastfeeding
• Acute colonoscopy
• Cancer screening program colonoscopy
• Mentally retarded
• Redo colonoscopy of patients included in this study and colonoscopy was canceled because of bad bowel preparation.
• Patients with Phenylketonuria
• Patients with Glucose-6-phosphate-dehydrogenase deficiency
• Patients with colon or rectum resection

Where it is running

• Aalborg University hospital — Aalborg, North Jutland, Denmark (enrolling)

Full record on ClinicalTrials.gov

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