Neurochemical Mechanisms of the Awake vs. Anesthetized Brain
Status unconfirmed · Early Phase 1
Conditions studied: Anesthesia, Healthy
In brief
The investigators will be studying the sedative drug dexmedetomidine using hybrid PET/fMRI/EEG imaging to better understand the neuropharmacology of anesthesia/artificially induced sleep.
Key facts
- Study ID
- NCT05435560
- Run by
- Massachusetts General Hospital
- People needed
- 30
- Starts
- 2022-04-12
- Expected to finish
- 2023-04-01
- Last updated by the study team
- 2022-06-28
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18-45.
- No contraindications to MRI or PET scanning.
You may not qualify if…
- Contraindications to fMRI scanning and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia);
- Pregnancy or breast feeding;
- Current or past history of major medical, neurological, or psychiatric condition;
- History of major head trauma;
- Any cardiovascular disorders, including heart disorders or high blood pressure [>155/95];
- Breathing problems such as severe asthma;
- Bleeding disorder, or use of anticoagulants;
- Bladder obstruction, urinary problems, or history of impaired elimination;
- Known kidney or liver problems;
- Intestinal blockage;
- Raynaud syndrome
- Peripheral nerve injury;
- Diabetes;
- Glaucoma;
- Sleep disorder, such as sleep apnea, insomnia, or narcolepsy
- Current use of any drugs that affect sleep
- Current or recent use of medications (neurological or psychiatric) affecting brain function
- Current or past history of chronic pain (assessed at discretion of PI);
- History of allergic reactions
- History of chronic obstructive pulmonary diseases
- Ulcerative skin conditions or other dermatologic conditions which could interfere with blood pressure cuff placement
- Body mass index above 30
- Current smoker
- Lack of current health insurance coverage
- Employed under the direct supervision of the investigators conducting the research
Where it is running
- Athinoula A. Martinos Center for Biomedical Imaging — Charlestown, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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