Mechanisms of Resistance to PSMA Radioligand Therapy
Recruiting now
Conditions studied: Prostate Cancer
In brief
This is a multicenter, correlative study to existing Lutetium based prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) trials and uses.
Key facts
- Study ID
- NCT05435495
- Run by
- University of California, San Francisco
- People needed
- 125
- Starts
- 2021-10-21
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-03-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Initiating treatment with Lutetium based PSMA-targeted RLT.
- Participants must have a PSMA-avid lesion that is accessible to biopsy. Biopsy of newly emerging radiographic metastases is desired and preferable to the biopsy of previously existing lesions whenever possible. Newly emerging lesions are defined as those that are absent on a previous scan, or those demonstrating unequivocal progression since initiation of the last treatment. Biopsies will be performed according to local institutional standards.
- Patients on warfarin, aspirin, or other anti-coagulants are eligible provided they are deemed able to tolerate discontinuation of anti-coagulation for at least five days prior to the biopsy. Conversion to low molecular weight heparin prior to biopsy is permitted per local standard operating procedures, provided there is approval by the interventional radiologist or the PI.
- Age >=18 years.
- Ability to understand and the willingness to sign a written informed consent document.
You may not qualify if…
- Patients with significant congenital or acquired bleeding disorders (eg von Wildebrand's disease, acquired bleeding factor inhibitors).
- Patients who are not able to undergo additional study related imaging procedures.
Where it is running
- University of California, Los Angeles — Los Angeles, California, United States (enrolling)
- University of California, San Francisco — San Francisco, California, United States (enrolling)
- Memorial Sloan Kettering — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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