A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC)

Completed · Phase 2

Conditions studied: Non-small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer, Nsclc, NSCLC Stage IV, Minimal Residual Disease, Non Small Cell Lung Cancer Metastatic

In brief

The purpose of this study is to see whether receiving local ablative therapy (LAT) when minimal residual disease/MRD levels are rising can reduce MRD levels and control metastatic non-small cell lung cancer/NSCLC longer compared to systemic therapy.

Key facts

Study ID

NCT05429320

Run by

Memorial Sloan Kettering Cancer Center

People needed

37

Starts

2022-06-15

Expected to finish

2026-01-28

Last updated by the study team

2026-02-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• At the time of therapeutic phase enrollment, complete response radiographically (no lesions to target)
• Patients with CNS-only disease (due to limited capacity of peripheral blood ctDNA to detect CNS lesions)
• Planned treatment by targeted agents (e.g. tyrosine kinase inhibitors) or patient not a candidate for systemic therapy
• Serious medical co-morbidities precluding radiotherapy or ablation, determined at the discretion of the treating investigator.
• At the time of therapeutic phase enrollment, pregnant or lactating women.
• Physical limitation to undergo stereotactic radiotherapy.
• Other active malignancy within the last year except for basal cell carcinoma of the skin and in situ malignancy even if without evidence of disease.

Where it is running

• Hartford Healthcare ALLIANCE (Data collection only) — Hartford, Connecticut, United States
• BAPTIST ALLIANCE - MCI (Data collection only) — Miami, Florida, United States
• Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey, United States
• Memorial Sloan Kettering Monmouth (Limited Protocol Activities) — Middletown, New Jersey, United States
• Memorial Sloan Kettering Bergen (Limited Protocol Activities) — Montvale, New Jersey, United States
• Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities) — Commack, New York, United States
• Memorial Sloan Kettering Westchester (Limited Protocol Activities) — Harrison, New York, United States
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States
• Memorial Sloan Kettering Nassau (Limited Protocol Activities) — Uniondale, New York, United States

Full record on ClinicalTrials.gov

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