Effects of Vitamin C Enriched Hydrolyzed Collagen, PrimaColl™, Whey Protein, or Placebo on Collagen Synthesis

Completed · Not applicable · Has a placebo group

Conditions studied: Effect of Food Supplement

In brief

The purpose of this study is to determine the effects of repeated dosing vitamin C enriched hydrolyzed collagen (HC) over a 24hr period, compared to PrimaColl™ (PC), whey protein (WP) and placebo (PL), with prescribed exercise on collagen synthesis. To achieve this, participants will consume a supplemental dose of HC (20g with 50mg vitamin C), PC (20g with 50mg vitamin C), whey protein (20g whey isolate with 50mg vitamin C) or a placebo (20g maltodextrin with 50mg vitamin C) 1hr prior to an exercise bout (6 minutes of jump rope), this will be repeated three times over a 24h period. The amount of collagen protein synthesized will be indirectly measured by measuring pro-collagen type I N-terminal propeptide (PINP) in the serum before and 4hrs after the last exercise bout.

Key facts

Study ID

NCT05427279

Run by

University of California, Davis

People needed

20

Starts

2022-10-05

Expected to finish

2024-09-30

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy active male or female
• normal weight (BMI between 18 and 25 kg/m2)

You may not qualify if…

• taking any medication that may interfere with the study
• have a history of more than 3 musculoskeletal injuries within the past 12 months
• have any health or dietary restriction that would be affected by the supplementation protocol

Where it is running

• Hickey Laboratory — Davis, California, United States

Full record on ClinicalTrials.gov

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