Risk Factors and Biomarkers for Post-tuberculosis Lung Damage

Recruiting now

Conditions studied: Pulmonary TB

In brief

This prospective study aims to determine the incidence of Post-tuberculosis lung damage (PTLD), examine trends in the changes in lung function, and investigate the impact of smoking and other factors on respiratory symptoms, lung function, and chest CT findings, which will aid in the development of prognostic and therapeutic strategies for PTLD.

Key facts

Study ID

NCT05426720

Run by

Peking University Third Hospital

People needed

400

Starts

2022-01-01

Expected to finish

2027-12-31

Last updated by the study team

2022-06-22

Who can join

Age: 25 and older, up to 60. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male patients aged 25-60 years newly diagnosed with active pulmonary TB.

You may not qualify if…

• patients with positive sputum smear or TB culture results;
• human immunodeficiency virus-positive patients;
• patients infected with multidrug-resistant TB;
• patients with malignant neoplasms (e.g., lung cancer) or severe cardiovascular and cerebrovascular diseases;
• non-compliant patients who were unable to complete the lung function tests;
• patients without lung parenchymal destruction (such as tuberculous pleurisy). -

Where it is running

• Peking University Third Hospital — Beijing, China (enrolling)
• Beijing Geriatric Hospital — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

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