Role of Sleep Reactivity in Shift Work Disorder

Recruiting now · Not applicable

Conditions studied: Shift-work Disorder

In brief

The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.

Key facts

Study ID: NCT05424406
Run by: Henry Ford Health System
People needed: 150
Starts: 2023-01-01
Expected to finish: 2027-10-01
Last updated by the study team: 2025-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants must be working a fixed nightshift schedule, operationalized as: a) working at least three night shifts a week, b) shifts must begin between 18:00 and 02:00, and last between 8 to 12 hours, and c) must also plan to maintain the nightshift schedule for the duration of the study
Participants must have Shift Work Disorder, which will be diagnosed based on ICSD-3 criteria
Participants must show circadian misalignment, operationalized as a baseline melatonin onset between 18:00 and 01:00.
Participants must be at least 18 years old

You may not qualify if…

Insomnia disorder or excessive sleepiness predating the onset of shift work
Termination of nightshift schedule
Presence of other sleep disorders (e.g. obstructive sleep apnea, narcolepsy) determined by standard clinical polysomnography
Diagnosis of bipolar disorder
History of neurological disorders determined by self-report and medical history
Pregnancy
Alcohol use disorder
Illicit drug use via self-report and urine drug screen if reasonable suspicion to test

Where it is running

Henry Ford Columbus Medical Center — Novi, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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