INSPIRE Trial for Abdominal Infections

Completed · Not applicable

Conditions studied: Abdominal (ABD) Infection

In brief

The INSPIRE Abdominal Infection Trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with abdominal infection is infected with a resistant pathogen. Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Key facts

Study ID

NCT05423743

Run by

Harvard Pilgrim Health Care

People needed

198480

Starts

2023-01-01

Expected to finish

2025-05-09

Last updated by the study team

2025-08-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Regional Medical Center of San Jose — San Jose, California, United States
• Good Samaritan Hospital — San Jose, California, United States
• Los Robles Hospital & Medical Center — Thousand Oaks, California, United States
• West Hills Hospital & Medical Center — West Hills, California, United States
• The Medical Center of Aurora — Aurora, Colorado, United States
• Swedish Medical Center — Englewood, Colorado, United States
• Sky Ridge Medical Center — Lone Tree, Colorado, United States
• North Suburban Medical Center — Thornton, Colorado, United States
• Blake Medical Center — Bradenton, Florida, United States
• Brandon Regional Hospital — Brandon, Florida, United States
• Oak Hill Hospital — Brooksville, Florida, United States
• Englewood Community Hospital — Englewood, Florida, United States
• Fort Walton Beach Medical Center — Fort Walton Beach, Florida, United States
• Lawnwood Regional Medical Center — Ft. Pierce, Florida, United States
• Regional Medical Center of Bayonet Point — Hudson, Florida, United States
• Memorial Hospital Jacksonville — Jacksonville, Florida, United States
• Lake City Medical Center — Lake City, Florida, United States
• Largo Medical Center — Largo, Florida, United States
• Northwest Medical Center — Margate, Florida, United States
• Mercy Hospital — Miami, Florida, United States
• Kendall Regional Medical Center — Miami, Florida, United States
• Orange Park Medical Center — Orange Park, Florida, United States
• Oviedo Medical Center — Oviedo, Florida, United States
• Gulf Coast Regional Medical Center — Panama City, Florida, United States
• Riverside Community Hospital — Riverside, California, United States

Full record on ClinicalTrials.gov

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