Neural Connectivity During Therapy for Adolescent PTSD

Recruiting now · Not applicable

Conditions studied: PTSD, Adolescent, Psychological Trauma

In brief

Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.

Key facts

Study ID

NCT05423444

Run by

The University of Texas Health Science Center at San Antonio

People needed

180

Starts

2022-11-29

Expected to finish

2027-02-28

Last updated by the study team

2026-01-13

Who can join

Age: 12 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ages 12-17 and Tanner stage 2 or above
• history of interpersonal trauma
• PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month

You may not qualify if…

• current or past use of psychiatric medications
• severe suicidal/homicidal ideation
• current hospitalization
• other current psychotherapy or previous treatment with TF-CBT
• history of head injury with loss of consciousness for >5 minutes
• IQ<85
• major medical illness
• MRI contraindications (metal in body; braces on teeth)
• psychosis, bipolar 1, autism, developmental disorder, panic disorder
• first-degree family member with diagnosis of psychosis or bipolar I disorder
• substance dependence within the past 3 months or current drug use that is frequent

Where it is running

• UT Health Department of Psychiatry — San Antonio, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.