Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease
Completed · Phase 1/Phase 2
Conditions studied: Aging
In brief
The purpose of this pilot study is to demonstrate the safety and feasibility of administering intermittent doses of Dasatinib and Quercetin (D+Q) in older adults at risk of Alzheimer's disease (AD). The study will evaluate whether giving D+Q may improve cerebral blood flow regulation, mobility, and cognition in older adults, and thus may prevent progression to Alzheimer's disease.
Key facts
- Study ID
- NCT05422885
- Run by
- Lewis Lipsitz
- People needed
- 15
- Starts
- 2022-05-20
- Expected to finish
- 2024-01-24
- Last updated by the study team
- 2025-03-17
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women >/= 65 years
- Ambulatory,
- Community dwelling,
- Slow gait speed (<1 m/second),
- Mild Cognitive Impairment (Telephone MoCA score <21, which is indicative of cognitive impairment)
- Exclusion Criteria, or as per clinical judgment:
- Telephone MoCA score <10 points
- Unwilling to take study medications or follow study protocol
- Inability to independently perform Katz Activities of Daily Living (ADLs),
- Allergies to Dasatinib or Quercetin,
- Hospitalization within 6 months,
- Unstable coronary artery disease (myocardial infarction within 6 months or angina),
- Stroke or transient ischemic attack in the past 6 months,
- Chronic heart failure,
- Current or chronic history of liver disease,
- Neurodegenerative disease including Parkinson's disease,
- Anemia,
- Chronic renal disease,
- Drug or alcohol abuse in the last 5 years,
- QTc prolongation,
- Thrombocytopenia,
- Neutropenia,
- Prolonged prothrombin time or INR,
- Indications of current fluid retention,
- History or current diagnosis of pulmonary hypertension,
Where it is running
- Hebrew Senior Life — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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