Department of Defense PTSD Adaptive Platform Trial - Master Protocol
Paused · Phase 2 · Has a placebo group
Conditions studied: Post Traumatic Stress Disorder
In brief
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design. Participants are randomized among the available cohorts in the study and the resulting randomization enables sharing/pooling of control participants, where all interventions may be compared to a common control (placebo). The master protocol describes the default procedures and analyses for all cohorts; treatment-specific eligibility requirements, safety and efficacy procedures, or endpoints are described in the cohort-specific appendices and reflected in the intervention-specific clinicaltrials.gov records.
Key facts
- Study ID
- NCT05422612
- Run by
- Global Coalition for Adaptive Research
- People needed
- 800
- Starts
- 2023-11-02
- Expected to finish
- 2029-07-01
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
Where it is running
- Homestead Associates in Research, Inc. — Miami, Florida, United States
- Advanced Discovery Research — Atlanta, Georgia, United States
- Tripler Army Medical Center (TAMC) — Tripler AMC, Hawaii, United States
- Cincinnati Veteran's Affairs Medical Center — Fort Thomas, Kentucky, United States
- Walter Reed National Military Medical Center (WRNMC) — Bethesda, Maryland, United States
- Upstate Clinical Research Associates, LLC — Williamsville, New York, United States
- Wilford Hall Ambulatory Surgical Center (WHASC) — San Antonio, Texas, United States
- Alexander T. Augusta Military Medical Center (ATAMMC): — Fort Belvoir, Virginia, United States
- Madigan Army Medical Center — Joint Base Lewis McChord, Washington, United States
Full record on ClinicalTrials.gov
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