Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age
Running, not enrolling · Phase 3
Conditions studied: Cystic Fibrosis
In brief
The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Key facts
- Study ID
- NCT05422222
- Run by
- Vertex Pharmaceuticals Incorporated
- People needed
- 210
- Starts
- 2022-06-21
- Expected to finish
- 2030-06-30
- Last updated by the study team
- 2026-05-28
Who can join
Age: 1 and older, up to 11. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Children's Hospital of Orange County — Orange, California, United States
- Stanford University Clinical and Translational Research Unit — Palo Alto, California, United States
- Children's Hospital of Colorado — Aurora, Colorado, United States
- The Emory Clinic / Children's Healthcare of Atlanta at Egleston — Atlanta, Georgia, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Riley Hospital for Children at Indiana University Health — Indianapolis, Indiana, United States
- Boston Children's Hospital — Boston, Massachusetts, United States
- Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota — Minneapolis, Minnesota, United States
- The Children's Mercy Hospital — Kansas City, Missouri, United States
- Washington University School of Medicine / St. Louis Children's Hospital — St Louis, Missouri, United States
- Cohen Children's Medical Center — Lake Success, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- Nationwide Children's Hospital — Columbus, Ohio, United States
- Oregon Health & Science University — Portland, Oregon, United States
- UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Texas Children's Hospital - Wallace Tower — Houston, Texas, United States
- Vermont Lung Center — Colchester, Vermont, United States
- American Family Childrens Hospital — Madison, Wisconsin, United States
- The Kids Research Institute Australia — Nedlands, Australia
- Women's and Children's Hospital — North Adelaide, Australia
- The Royal Children's Hospital — Parkville, Australia
- Queensland Children's Hospital — South Brisbane, Australia
- The Hospital for Sick Children — Toronto, Canada
- British Columbia Children's Hospital — Vancouver, Canada
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.