Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

Recruiting now · Phase 4

Conditions studied: Hypertension

In brief

Study design: Investigator initiated, single center The study is aimed 1\) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1\) to verify the cutoff value (RNS-induced systolic BP change \<20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN therapy, and test the hypothesis that intense RDN could improve the efficacy of RDN.

Key facts

Study ID

NCT05421767

Run by

National Taiwan University Hospital

People needed

60

Starts

2022-06-24

Expected to finish

2027-12-31

Last updated by the study team

2022-06-16

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with hypertension (HTN), including
• 24-hour ambulatory blood pressure >130/ 80 mmHg
• Age 20-80 years
• Glomerular filtration rate >45 mL/min

You may not qualify if…

• Unsuitable renal artery anatomy computed tomographic angiography (main renal artery lumen diameter ≤3 mm or a total length <20 mm of the main arteries).
• untreated secondary HTN, including hyperaldosteronism, pheochromocytoma, renal artery stenosis(>50% stenosis)

Where it is running

• National Taiwan University Hospital — Taipei, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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