Audio-vestibular Evaluation of Children and Young Adults With Osteogenesis Imperfecta

Recruiting now

Conditions studied: Osteogenesis Imperfecta

In brief

The aim is to determine whether vestibular deficits are present in OI, then to establish whether a correlation exists between genetic type, severity of OI and audiovestibular phenotype. OI patients aged 12 to 20 years will undergo an audiometric, immittance, and vestibular assessment. When hearing loss is conductive or mixed or in cases where vestibular deficits are identified, a CT scan without injection will be performed. In case of sensorineural hearing loss or abnormal CT results, an MRI will be performed.

Key facts

Study ID

NCT05419960

Run by

Assistance Publique - Hôpitaux de Paris

People needed

44

Starts

2022-12-22

Expected to finish

2027-12-22

Last updated by the study team

2025-09-12

Who can join

Age: 12 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients between the ages of 12-20 years at the time of inclusion
• Diagnosis of Osteogenesis Imperfecta of any type
• Currently followed by a physician at the CRMR OI
• Information and non-opposition of major patients, holders of parental authority and minor patients to participate in the study

You may not qualify if…

• Patients with hearing loss of alternate origin e.g. Cochlear nerve deficiency, atresia, etc.
• Neurological or developmental deficits limiting participation
• Cervico-occipital instability e.g. Chiari's malformation
• Limitations in mobility of the spine e.g. scoliosis, spinal fractural fusion
• Ophthalmologic pathologies e.g. strabism or severe refraction disorder
• Patients under AME (State Medical Aid)
• Protected adult patients, adults unable to express their consent, pregnant or breastfeeding women

Where it is running

• Hôpital Necker-Enfants Malades — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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