A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain
Recruiting now · Phase 2
Conditions studied: Lung Cancer, Lung Cancer Metastatic, Brain Metastases, Brain Metastases, Adult, Small-cell Lung Cancer, Small Cell Lung Carcinoma
In brief
The purpose of the study is to see if stereotactic radiosurgery/SRS is an effective treatment for people with a new diagnosis of brain metastases from small cell lung cancer/SCLC.
Key facts
- Study ID
- NCT05419076
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 62
- Starts
- 2022-06-10
- Expected to finish
- 2027-06-10
- Last updated by the study team
- 2026-06-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologic diagnosis of small cell lung cancer
- Radiographic diagnosis of up to 20 brain metastases on contrast-enhanced MRI
- Age 18 and above
- Performance status KPS 60-100/ECOG 0-2
- Female patients must be of non-reproductive potential or have a negative serum pregnancy test at the time of enrollment
- The patient or legally authorized representative is able to provide informed consent
You may not qualify if…
- Unable to undergo contrast-enhanced MRI brain
- Leptomeningeal disease confirmed on lumbar puncture, MRI brain, or MRI spine
- Pregnant or lactating women
- Prior brain-directed radiotherapy
- Uncontrolled systemic disease without reasonable systemic therapy options felt likely to result in death as observed on CT or PET/CT imaging, no more than 3 months before study enrollment
Where it is running
- Memorial Sloan Kettering at Basking Ridge — Basking Ridge, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States (enrolling)
- Memorial Sloan Kettering Suffolk - Commack — Commack, New York, United States (enrolling)
- Memorial Sloan Kettering Westchester — Harrison, New York, United States (enrolling)
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
- Memorial Sloan Kettering Nassau — Rockville Centre, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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