Inhaled Isopropyl Alcohol for Treatment of Nausea

Recruiting now · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Vomiting, Nausea, Children, Only

In brief

To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.

Key facts

Study ID

NCT05418244

Run by

State University of New York at Buffalo

People needed

84

Starts

2022-04-20

Expected to finish

2026-06-30

Last updated by the study team

2025-10-08

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with a chief complaint of nausea or vomiting
• Ages 7-178 years, both sexes
• Weight ≥ 15 kg
• Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10

You may not qualify if…

• 1. Require IV access
• Inability to breathe in/out through the nose
• Anosmia (self- or parental report)
• Allergy to isopropyl alcohol or ondansetron
• Current or history of alcohol abuse
• Inability to communicate feeling nauseous
• Inability to follow directions regarding taking deep breaths through the nose
• Known prolonged QT interval
• Pregnancy
• Received antiemetics within the last 8 hours
• Currently taking apomorphine

Where it is running

• Oishei Children's Hospital — Buffalo, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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