Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).

Recruiting now

Conditions studied: Mechanical Ventilation Complication, Hyperoxia

In brief

The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.

Key facts

Study ID

NCT05412810

Run by

Ohio State University

People needed

200

Starts

2023-03-01

Expected to finish

2026-09-01

Last updated by the study team

2024-04-26

Who can join

Age: 18 and older, up to 110. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults age => 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours

You may not qualify if…

• 1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others
• 2)Chronic respiratory failure prior to admission;
• 3)Hemoptysis or diffuse alveolar hemorrhage
• 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements.
• 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;

Where it is running

• Ohio State University Medical Center — Columbus, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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