Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)

Recruiting now · Not applicable

Conditions studied: Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis, Oesophageal Cancer, Gastric Cancer, Volatalomics, Metabonomics/Lipidomics, Microbiome Analysis, Transcriptomics

In brief

Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific. The study team has developed a non-invasive test for cancers of the stomach and oesophagus based on the detection of volatile organic compounds in exhaled breath. These compounds are known to be produced by both cancers as well as cancer associated bacteria within the gut. The proposed innovation is to improve the accuracy of this test by investigating whether simple metabolic substrates can increase the production of these volatile organic compounds by both the tumour and its associated bacteria.

Key facts

Study ID
NCT05412758
Run by
Imperial College London
People needed
648
Starts
2022-02-28
Expected to finish
2025-10-01
Last updated by the study team
2025-01-31

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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