Once Weekly Infant Corticosteroid Trial for DMD

Recruiting now · Phase 4

Conditions studied: Duchenne Muscular Dystrophy

In brief

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.

Key facts

Study ID

NCT05412394

Run by

Anne M. Connolly

People needed

26

Starts

2021-04-30

Expected to finish

2026-12-01

Last updated by the study team

2025-08-13

Who can join

Age: 0 and older, up to 3. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Subjects ages 1 month through 30 months
• Weakness consistent with Duchenne on exam, creatine kinase ≥ 20 times the upper limit of normal, and genetic mutation known to be causative for DMD.

You may not qualify if…

• Prior treatment with Glucocorticosteroids

Where it is running

• Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)
• Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
• University of Texas Southwestern — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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