PRP in ACLR to Prevent PTOA

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, PRP

In brief

The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.

Key facts

Study ID

NCT05412381

Run by

Hospital for Special Surgery, New York

People needed

56

Starts

2022-06-27

Expected to finish

2026-12-31

Last updated by the study team

2026-02-13

Who can join

Age: 14 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute ACL injury within 6 weeks of presentation
• Age 14-50
• Male or female
• Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)

You may not qualify if…

• Prior ACL reconstruction
• Prior cartilage repair procedure
• Prior meniscus surgery within 12 months
• Prior steroid, hyaluronic acid, or PRP injection within 6 months
• Other ligament injury requiring repair
• Any cartilage lesion requiring repair
• Any cartilage lesion greater than grade 2 (partial thickness injury)
• History of inflammatory arthritis or joint sepsis
• Non English speakers

Where it is running

• Hospital for Special Surgery — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.