Hybrid Ablation of Atrial Fibrillation in Heart Failure
Recruiting now · Not applicable
Conditions studied: Persistent Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrial Arrhythmia, Atrial Fibrillation, Heart Failure, Left Ventricular (LV) Systolic Dysfunction
In brief
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
Key facts
- Study ID
- NCT05411614
- Run by
- St. George's Hospital, London
- People needed
- 120
- Starts
- 2022-06-25
- Expected to finish
- 2027-10-01
- Last updated by the study team
- 2025-11-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Persistent or Long-standing Persistent AF
- Dilated left atrium (at least moderately dilated)
- Suitable for either procedure
- LVEF < 50%
You may not qualify if…
- Not yet optimised from a medical or lifestyle perspective for AF or heart failure
- Unable to provide written consent
- Previous open-heart surgery
- Active infection, oesophageal ulcer stricture or oesophageal varices
- Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
- Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation
- Severe valvular heart disease
- Unstable coronary artery disease
- Uncontrolled ventricular arrhythmia
- Heart attack or stroke within the last 90 days
- Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months
- Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures
Where it is running
- St Georges University of London — London, United Kingdom (enrolling)
- Ashford & St Peters Hospital NHS Trust — Chertsey, United Kingdom (enrolling)
- Epsom General Hospital — Epsom, United Kingdom (enrolling)
- St Georges at Kingston Hospital — London, United Kingdom (enrolling)
- Royal Surrey County Hospital — London, United Kingdom (enrolling)
- St Anthonys Hospital — London, United Kingdom
- Cromwell Hospital — London, United Kingdom
Full record on ClinicalTrials.gov
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