Study of Role of Blood Microvescicles and Exosomes in Patients With Graft Occlusion After Aortocoronary Bypass Surgery

Recruiting now

Conditions studied: Coronary Artery Bypass Surgery

In brief

Coronary artery bypass graft (CABG) surgery is still the standard treatment of coronary revascularization for patients with severe coronary artery disease (CAD). Graft patency, together with completeness of revascularization, is a major determinant of long-term outcome following CABG. The surgical procedure elicits a persistent systemic inflammatory response associated with the activation of the hemostatic system leading to perturbation of endothelial and vascular function and activation of platelets and leukocytes. All of these events are the main players responsible for the early and late graft failure in a significant percentage of patients.

Key facts

Study ID

NCT05411445

Run by

Maria Cecilia Hospital

People needed

300

Starts

2022-06-01

Expected to finish

2025-09-01

Last updated by the study team

2024-08-28

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• between the ages of 40 and 80
• Ejection fraction> 30%
• coronary artery bypass surgery
• informed consent
• Willingness to carry out the follow-up visits and the assessments required by the protocol

You may not qualify if…

• emergency intervention
• changes in liver or kidney function
• changes in coagulation factors
• associated interventions (valve replacement, carotid endarterectomy)

Where it is running

• MCH — Cotignola, Ravenna, Italy (enrolling)

Full record on ClinicalTrials.gov

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