Basal Plasma Lithium Levels and Suicidal Events

Recruiting now

Conditions studied: Major Depressive Disorder, Suicidal Behavior, Bipolar Disorder

In brief

Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk. Apart from drug treatments, lithium is present in our environment and its levels varies from one individual to another, depending, especially, on diet. Knowing that patients with a mood disorder generally have a poor lifestyle and a less rich and varied diet than the general population, variations in basal lithium levels can be expected in these patients.

Key facts

Study ID: NCT05409794
Run by: University Hospital, Montpellier
People needed: 158
Starts: 2022-12-09
Expected to finish: 2027-01-09
Last updated by the study team: 2024-08-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

18 years old or over
Current major depressive episode according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria
No lithium-based treatment over the last 12 months
For suicide attempters/ideations only : suicidal event over the last 12 months
For affective controls only : no suicidal event over the last 12 months

You may not qualify if…

Lifetime diagnosis of schizoaffective disorder, schizophrenia or psychosis
Pregnancy or breastfeeding
Deprivation of freedom (by judicial or administrative decision)
Legal protection measure (guardianship or curators)
Inability to understand experimental procedures
No affiliation to the French National Social Security System
No consent to participate in the study

Where it is running

CHU Montpellier — Montpellier, France (enrolling)

Full record on ClinicalTrials.gov

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