Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Completed · Phase 2 · Has a placebo group
Conditions studied: Bipolar Disorder
In brief
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead. Transcranial light therapy has been found to promote brain metabolism, which may help improve executive function in people with bipolar disorder. The research team proposes a novel approach to treating bipolar disorder by using transcranial light therapy.
Key facts
- Study ID
- NCT05408637
- Run by
- Paolo Cassano
- People needed
- 13
- Starts
- 2022-08-09
- Expected to finish
- 2024-05-14
- Last updated by the study team
- 2025-08-28
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults between the ages of 18 and 65
- Diagnosis of bipolar disorder
- Currently experiencing symptoms of impulsivity
- Vision normal or corrected to normal with contacts
You may not qualify if…
- Currently in depressive, manic, or mixed episode
- Currently psychotic
- Judged to be at serious and imminent suicidal risk
- Currently in alcohol or substance use disorder (meeting criteria in the past 3 months)
- Unstable medical conditions
- Inability to consent or to complete study procedures
- Failure to meet standard MRI safety requirements (e.g. claustrophobia, non-removable piercings, implanted medical devices, other non-removable metals)
- Changes in medications or use of augmentative devices and other interventions in the 2 weeks prior to the study
- Participation in other clinical research trials that may influence primary outcomes or adherence to the proposed study
- Current pregnancy.
Where it is running
- Mass General Hospital Navy Yard Building 149 — Charlestown, Massachusetts, United States
Full record on ClinicalTrials.gov
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