Biomarkers for Invasive Mucormycosis
Recruiting now
Conditions studied: Mucorales Infection, Mucormycosis
In brief
Mucormycosis (MM) is one of the main invasive fungal infection (IFI), and is determined by filamentous fungi belonging to the order of Mucorales, with a mortality rate ranging from 20 to 60% according to localization. Prompt initiation of adequate antifungal therapy is critical for treating mucormycosis. Early diagnostic is therefore essential. The presence in the Mucorales' cell wall of uncommon monosaccharides open interesting perspectives for the development of specific diagnostic biomarkers. This study evaluate a diagnostic test for mucormycosis in a cohort of patients with MM and in control groups (high-risk patients without MM and patients with another IFI).
Key facts
- Study ID
- NCT05406037
- Run by
- University Hospital, Lille
- People needed
- 100
- Starts
- 2023-11-29
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2026-05-22
Who can join
Age: 3 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women
- Age : Children and adults from 3 to 64 years old (18 to 64 for controls)
- In patients whose consent has been collected after information. In the case of children, information on the study will be given to the holders of parental authority and then to the child to obtain their consent.
- Patient social insured
- Specific medical conditions :
- For the case group :
- Any patient hospitalized in one of the departments of the University Hospital of Lille, in which the diagnosis of mucormycosis was conducted on the following criteria:
- Conventional mycology data and / or
- Positivity of q-PRC and / or
- Anatomopathologic diagnosis Associated with a compatible clinical situation
- For the control group 1 Patient assessed for hematopoietic stem cell transplantation, considered at risk for IFI but for whom the pre-transplantation review will have excluded an ongoing infection
- For control group 2 Any patient hospitalized in a department of Lille University Hospital, in which the diagnosis of disseminated candidiasis or invasive pulmonary aspergillosis has been made according to specific classifications (EORTC/MSG criteria, AspICU criteria)
You may not qualify if…
- Patients for whom the inclusion criteria are not met
- Co-infection mucormycosis/other IFI
Where it is running
- University Hospital of Lille — Lille, Hauts-de-France, France (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.