AZA + Venetoclax as Maintenance Therapy in Younger Adults With AML in First Remission

Recruiting now · Phase 2/Phase 3

Conditions studied: Acute Myeloid Leukemia (AML) in Remission

In brief

This phase III trial is conducted to evaluate if azacitidine in combination with venetoclax as maintenance therapy improves relapse-free survival (RFS) for younger adults with favorable-risk acute myeloid leukemia (AML) who remained in first complete remission (CR1) following intensive consolidation.

Key facts

Study ID: NCT05404906
Run by: The First Affiliated Hospital of Soochow University
People needed: 124
Starts: 2022-06-25
Expected to finish: 2030-06-01
Last updated by the study team: 2022-08-19

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Diagnosis of favorable-risk acute myeloid leukemia (AML) according to revised 2017 European LeukemiaNet genetic risk stratiﬁcation and are not immediate candidates for allogeneic stem cell transplant.
Aged 18-64 years.
Patients who have received remission induction therapy and 3-4 HiDAC or medium-dose cytarabine-based consolidation and are in their first remission.
ECOG performance status of < or = 3.
Adequate organ function as follows:
Serum total bilirubin < or = to 3 X the Upper Limit of Normal (ULN)
Aspartate Transaminase and alanine transaminase < or = to 3 x ULN
Ccr（Creatinine Clearance Rate) > or ＝60 ml/min
Left ventricular ejection fraction > or ＝50% determined by ultrasound.
For females of childbearing age, they should have a negative serum or urine pregnancy test within 10 to 14 days of enrolling.
For males of childbearing age, they should take effective contraceptive methods throughout the treatment period and up to 30 days after discontinuing treatment.
Ability to understand and sign informed consent.

You may not qualify if…

Acute promyeloid leukemia.
Patients with active central nervous system (CNS) leukemia.
Previously diagnosed with myelodysplastic syndrome (MDS) or myeloproliferative neoplasm(MPN) and progressed to AML.
Patients with other progressive malignancies.
Evidence of other clinically significant uncontrolled condition(s) including, but not limited to uncontrolled and/or active systemic infection (viral, bacterial or fungal).
Patients who have participated in other trials within 30 days before signing the informed consent.
Females who are pregnant or lactating or intending to become pregnant during the study.

Where it is running

First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China (enrolling)
The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology — Suzhou, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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