Sleep Disturbances and Delirium

Recruiting now · Not applicable

Conditions studied: Sleep Disturbance

In brief

Delirium is a frequent and serious problem in hospitalized patients; it is associated with multiple hospital-acquired complications. There is evidence that the incidence of deliri-um may be minimized by multimodal interventions (pain management, shortening the duration of mechanical ventilation, light sedation, avoiding benzodiazepines, routine delirium monitoring, and early mobilization). Even though a clear association between sleep and delirium has not been established, many studies suggest that sleep disturban-ces may be a key risk factor for the development of delirium. Therefore, sleep promoti-on is becoming an integral part of clinical care. The project support the hypothesis that non-pharmacological preventive interventions promoting sleep (sleep protocol) positive-ly influence the quality of sleep and reduce the incidence of delirium in hospitalized patients. This will be verified by qualitative and quantitative research methods, with the quantitative study being divided into three prospective cross-sectional studies and one interventional study. Data will be obtained from 3240 hospitalized patients by combi-ning subjective methods (questionnaire surveys) and objective measurements (acti-graphy). The project outcomes will allow better understanding of the relationship betwe-en sleep and delirium. A set of non-pharmacological preventive interventions promoting sleep will be developed, with a subsidiary aim to potentially reduce the incidence of delirium in hospitalized patients.

Key facts

Study ID

NCT05402280

Run by

University of Ostrava

People needed

3240

Starts

2022-05-01

Expected to finish

2025-12-31

Last updated by the study team

2025-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age over 18 years
• a hospital stay longer than 24 hours
• a hospital stay longer than 36 hours
• hospitalized for at least 72 hours, without previous sleep disturbances, without cognitive impairment

You may not qualify if…

• Patients with cognitive impairment preventing them from cooperating
• Glasgow Coma Scale score below 12
• terminal disease
• previous and current treatment for sleep disturbances
• neurocognitive dysfunction (dementia)
• sedative administration over the last 24 hours

Where it is running

• University of Ostrava — Ostrava, Česká Republika, Czechia (enrolling)

Full record on ClinicalTrials.gov

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