An Efficacy and Safety Study of RPT193 in Adults With Atopic Dermatitis

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Atopic Dermatitis

In brief

Phase 2 study of RPT193 in adults with atopic dermatitis

Key facts

Study ID

NCT05399368

Run by

RAPT Therapeutics, Inc.

People needed

229

Starts

2022-06-07

Expected to finish

2024-05-24

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinically confirmed diagnosis of active atopic dermatitis (AD), according to the revised Hanifin and Rajka criteria
• 12-month history of AD and had no significant flares in AD for at least 4 weeks before screening
• inadequate response to a ≥1 month treatment with topical medications
• Atopic dermatitis covering ≥10% of the body surface area
• EASI score ≥16
• Validated Investigator Global Assessment (VIGA) ≥3
• Use of emollient(s) at least 2x daily for 1 week prior to baseline
• Negative coronavirus disease (COVID)-19 results at screening

You may not qualify if…

• Uncontrolled moderate-to-severe asthma
• Uncontrolled diabetes
• Stage III or IV cardiac failure
• Severe renal condition
• Major surgery within 8 weeks of screening
• Immunodeficiency and/or receipt of immunosuppressive drugs within 4 weeks of baseline
• Use of systemic Janus kinase (JAK) inhibitor within 8 weeks of baseline
• Received live or live-attenuated vaccine within 4 weeks of baseline
• Prior receipt of RPT193

Where it is running

• Perseverance Research Center — Scottsdale, Arizona, United States
• Arkansas Research Trials, LLC — North Little Rock, Arkansas, United States
• California Dermatology & Clinical Research Institute — Encinitas, California, United States
• First OC Dermatology — Fountain Valley, California, United States
• Grimes Center — Los Angeles, California, United States
• Dermatology Research Associates — Los Angeles, California, United States
• Wallace Medical Group — Los Angeles, California, United States
• Velocity Clinical Research — North Hollywood, California, United States
• Integrative Skin Science and Research — Sacramento, California, United States
• Clinical Science Institute — Santa Monica, California, United States
• Clinical Trials Research Institute — Thousand Oaks, California, United States
• Foxhall Research Center — Washington D.C., District of Columbia, United States
• Driven Research LLC — Coral Gables, Florida, United States
• Florida Academic Centers Research and Education, LLC — Coral Gables, Florida, United States
• Palm Beach Dermatology Group — Delray Beach, Florida, United States
• GSI Clinical Research — Margate, Florida, United States
• Lenus Research & Medical Group, LLC — Sweetwater, Florida, United States
• Forcare Clinical Research — Tampa, Florida, United States
• Skin Care Physicians of Georgia — Macon, Georgia, United States
• Marietta Dermatology Clinical Research, Inc. — Marietta, Georgia, United States
• Georgia Skin & Cancer Clinic — Savannah, Georgia, United States
• University Dermatology and Vein Clinic — Darien, Illinois, United States
• Indiana Clinical and Translational Sciences Institute (CTSI) Clinical Research Center — Indianapolis, Indiana, United States
• Dawes Fretzin Clinical Research Group, LLC — Indianapolis, Indiana, United States
• Cahaba Dermatology and Skin Health Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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