A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Enrolling by invitation · Not applicable
Conditions studied: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
In brief
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability of two suicide prevention strategies tailored for autistic individuals: the Safety Planning Intervention tailored for Autistic individuals (SPI-A) and SPI-A plus structured follow-up contacts (SPI-A+).
Key facts
- Study ID
- NCT05398250
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 1665
- Starts
- 2022-08-23
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2026-02-10
Who can join
Age: 12 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 12-24 years old
- Scheduled for a clinical visit with a consented clinician Exclusion criteria: None
- A.2 - Enhanced EHR-Only Arm:
- Inclusion criteria:
- Meets inclusion criteria for the Basic EHR-Only arm
- Receives one of the interventions being studied (SPI-A or SPI-A+) as part of routine clinical care
- Exclusion criteria: Presence of documentation that the patient declines all research participation
- A.3 - Active PRO Arm:
- Inclusion Criteria:
- Meets inclusion criteria for the Enhanced EHR-Only arm
- Referred to the study team by a consented clinician
- Able and willing to provide informed consent (age 18+) or assent and parental/guardian consent (age < 18)
- Able to speak English (and, if applicable, at least one guardian also able to speak English)
- Exclusion Criteria: Altered mental status that precludes ability to provide informed assent or consent (acute psychosis, intoxication, or mania)
- (B) Clinician Participants
- Inclusion Criteria:
- Employment as a provider serving autistic patients at one of the study sites
- Employment in a role that involves suicide risk intervention with youth patients at a participating clinic
- Able to read and speak English
- Able and willing to provide informed consent
- Exclusion Criteria: None
- (C) Health System Leader Participants
- Inclusion Criteria:
- Health system or clinic leader at one of the study sites
- Employed in a role that provides administrative oversight to clinicians conducting safety plans with patients
Where it is running
- Kennedy Krieger Institute — Baltimore, Maryland, United States
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- Nationwide Children's Hospital — Columbus, Ohio, United States
- Children's Hospital of Pennsylvania — Philadelphia, Pennsylvania, United States
- Seattle Children's Hospital — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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