Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
Recruiting now · Not applicable
Conditions studied: Intracranial Artery Stenosis
In brief
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C\>1.8mmol/L) without endovascular therapy.
Key facts
- Study ID
- NCT05397405
- Run by
- Nanjing First Hospital, Nanjing Medical University
- People needed
- 180
- Starts
- 2022-05-23
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
- low density lipoprotein cholesterol > 70mg/dl (1.8mmol/L)
- Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
- Lipid-lowering indications of statins
- Signed an approved informed consents
You may not qualify if…
- Contraindications to statins
- There are contraindications to MRI examination or cannot accept MRI examination
- Stenosis caused by vasculitis, arterial dissection and moyamoya disease
- Patients with active bleeding or obvious bleeding tendency
- Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating
- Uncontrolled severe diabetes and hypertension
- Other conditions inappropriate for inclusion judged by investigators
Where it is running
- Nanjing First Hospital, Nanjing Medical University — Nanjing, Jiangsu, China (enrolling)
- Nanjing First Hospital — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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