Blood Vessel Anatomy and Blood Flow Regulation

Running, not enrolling

Conditions studied: Brain Blood Flow, Healthy

In brief

Brain blood flow regulation will be measured in response to environmental changes using MRI.

Key facts

Study ID

NCT05396287

Run by

University of Wisconsin, Madison

People needed

80

Starts

2022-07-19

Expected to finish

2027-05-01

Last updated by the study team

2026-07-07

Who can join

Age: 55 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI ≤38.5 kg/m2
• Nonsmoker
• Female subjects: postmenopausal
• Currently enrolled in the Wisconsin Alzheimer's Disease Research Clinical Core

You may not qualify if…

• Diagnosis of mild cognitive impairment or Alzheimer's disease
• Uncontrolled hypertension
• History or evidence of hepatic disease, hematological disease, or peripheral vascular disease
• Severe kidney injury requiring hemodialysis
• Cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
• History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
• History of HIV/AIDS
• Severe untreated obstructive sleep apnea
• History of diabetes with HbA1c greater than 9.5%
• Major neurologic disorders other than dementia (e.g., multiple sclerosis, amyotrophic lateral sclerosis, brain surgery, etc.)
• Current or recent (<1 year) major psychiatric condition (Axis I) or addictive disorders
• Contraindications to MRI

Where it is running

• University of Wisconsin-Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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