LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study

Recruiting now · Not applicable

Conditions studied: ACL

In brief

The Anterior Cruciate Ligament (ACL) is a major stabiliser of the knee. ACL rupture is being increasingly identified in children and skeletally immature patients. The current advice in younger patients is usually to undergo ACL reconstruction. The choice of an ideal graft in children is difficult This study will use a technique involves the use of hamstring tendons from a living donor, where the adult (usually a parent) agrees to donate their hamstring tendons, which are dissected out of them and implanted into the child

Key facts

Study ID

NCT05395767

Run by

Maidstone & Tunbridge Wells NHS Trust

People needed

40

Starts

2021-09-15

Expected to finish

2028-09-01

Last updated by the study team

2026-07-29

Who can join

Age: 8 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients aged 8 to 17 years inclusive and have a clinically and radiologically confirmed ACL rupture that requires reconstruction.
• Patients who have had previous surgery for meniscal pathology .
• Patients with current meniscal pathology
• The child and their responsible adult are in agreement with the choice to undergo anterior cruciate ligament reconstruction using living donor allograft.
• Donors has not previously undergone tendon harvest on the chosen donor limb
• Patients are willing to attend follow up appointments and agree to fill in knee questionnaires and allow instrumented knee ligament testing.

You may not qualify if…

• Patients who have previously undergone ACL surgery on the same limb (and therefore require revision surgery)
• Patients who are immunosuppressed, or receiving immunosuppressive therapy
• Patients who are unable to attend follow-up appointments for continued research purposes.
• Donors who have previously undergone hamstring tendon surgery on the donor limb
• Patients and donors who have a positive screening blood test for any of the transmissible infections tested
• Donors whose answers to the 'Donor Documentation Questionnaire' indicate that there could be a risk of transmissible infection, may not included
• Donors who are not considered healthy enough to undergo a tenotomy under General anaesthetic

Where it is running

• Trauma & Orthopaedic Dept, Tunbridge Wells Hospital — Pembury, Kent, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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