Quality of Life and Surgery in Diverticular Disease

Recruiting now

Conditions studied: Diverticulitis Colon, Quality of Life, Diverticular Disease of Left Side of Colon

In brief

Diverticular disease is one of the most common diseases of the gastrointestinal tract in industrial countries. Prevalence and admission rate due to diverticular disease increases. Symptomatic patients usually present with acute uncomplicated or complicated diverticulitis. Recurrence rates of complicated diverticulitis are estimated to 10-30%. Recurrences, chronic complications or persisting pain, here collectively referred to as chronic diverticular disease, may be treated by elective sigmoidectomy. Currently, there is no specific criteria for elective surgery, but only a recommendation of a tailored approach depending on the patient's symptoms. It is well established that diverticular disease has a negative impact on quality of life (QoL). Elective laparoscopic sigmoidectomy may increase QoL. In this prospective study, we will prospectively examine QoL, patient-related outcomes and peri- and postoperative outcome of elective sigmoidectomy for chronic diverticular disease, and compare it to conservatively treated patients.

Key facts

Study ID

NCT05393609

Run by

University of Aarhus

People needed

250

Starts

2022-04-22

Expected to finish

2027-12-01

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Referred to surgical clinic due to diverticular disease
• Colonic diverticula verified by CT or endoscopy

You may not qualify if…

• Previous colonic resection other than appendectomy
• Previous or current colorectal cancer
• Previous or current disseminated cancer
• Inflammatory bowel disease
• Psychiatric disorder influencing the ability to answer questionnaires
• Inadequate Danish

Where it is running

• Randers Regional Hospital — Randers, Central Jutland, Denmark (enrolling)

Full record on ClinicalTrials.gov

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