MicroRNA Regulation of Chronic Inflammation During Aging

Recruiting now

Conditions studied: Chronic Inflammation

In brief

This is an observational study enrolling healthy individuals aged 18-35 and 65y and older to determine the health of immune cells in the blood and how these cells create inflammation and effect health as we age. It is hoped that once the nature of this relationship has been discovered we can more effectively design therapies to reduce this inflammation. The enrollment goal is 40 participants. The study will occur over the course of 1 month which will include a screening visit and a second visit where the participants will undergo an oral glucose tolerance test, blood draws and leg strength \& exercise tests.

Key facts

Study ID

NCT05392582

Run by

University of Utah

People needed

40

Starts

2024-11-12

Expected to finish

2028-01-01

Last updated by the study team

2025-12-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 - 35y; 65y and older
• BMI: <30 kg/m2
• Ability to sign informed consent
• For older participant group: Clinical Frailty Scale score < 3 and Mini-Cog score > 3
• Good general medical health, ambulatory and in independent living setting

You may not qualify if…

• History of cardiovascular disease (e.g., CHF, CAD, MI, CVA)
• History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted)
• History of kidney disease or failure (CKD > stage 4)
• History of vascular disease
• Uncontrolled hypertension - Elevated systolic pressure >150 or a diastolic blood pressure > 100
• Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
• Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted)
• Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment
• Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C
• History of stroke with motor disability
• A recent history (<12 months) of GI bleed
• History of liver disease or AST/ALT 2 times above the normal limit
• History of respiratory disease (acute upper respiratory infection, history of chronic lung disease)
• Current smokers or current tobacco use
• Current pregnancy as determined by positive pregnancy test
• Any staff members who report directly to the principal investigators.

Where it is running

• The University of Utah — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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