A Study to Assess the Long-Term Safety and Efficacy of Donidalorsen in the Prophylactic Treatment of Hereditary Angioedema (HAE)

Running, not enrolling · Phase 3

Conditions studied: Hereditary Angioedema

In brief

The purpose of this study is to evaluate the long-term safety and efficacy of donidalorsen in people with HAE and the effects of donidalorsen on the number of HAE attacks and their impact on quality of life (QoL).

Key facts

Study ID

NCT05392114

Run by

Ionis Pharmaceuticals, Inc.

People needed

154

Starts

2022-07-13

Expected to finish

2027-03-01

Last updated by the study team

2025-12-12

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants and, as applicable, legally authorized representatives (i.e., parent(s)/legal guardian), must provide written and signed informed consent form (ICF).
• Participants must have access to, and the ability to use, ≥ 1 acute medication(s) (e.g., plasma-derived or recombinant C1-INH concentrate or a bradykinin receptor (BK) 2-receptor antagonist) to treat angioedema attacks.
• Open-Label Extension Participants ONLY:
• Satisfactory completion of ISIS 721744-CS5 (randomized placebo-controlled index study) through Week 25 or participants who are allowed to exit ISIS 721744-CS5 study per protocol with an acceptable safety and tolerability profile.
• New (not previously on donidalorsen) Participants ONLY:
• Participants must be aged ≥ 12 years at the time of informed consent and, as applicable, assent.
• Participants must have a documented diagnosis of HAE-1/HAE-2.
• Participants must be on a stable dose (≥ 12 weeks) of prophylaxis treatment with lanadelumab or berotralstat or SC C1-esterase inhibitor prior to the Screening Period.

You may not qualify if…

• Open-Label Extension Participants:
• Have any new condition or worsening of an existing condition or change or anticipated change in medication.
• New (not previously on donidalorsen) Participants ONLY:
• Concurrent diagnosis of any other type of recurrent angioedema, including acquired, idiopathic angioedema or HAE with normal C1-INH (also known as HAE Type III).
• Anticipated change in the use of concurrent androgen or tranexamic acid prophylaxis used to prevent angioedema attacks.
• Any clinically-significant abnormalities in screening laboratory values.
• Malignancy within 5 years of Screening, except for non-melanoma skin cancers, cervical in situ carcinoma, breast ductal carcinoma in situ, or stage 1 prostate carcinoma that has been successfully treated.
• Hypersensitivity to the active substance (donidalorsen) or to any of the excipients.
• Treatment with another investigational drug (non-oligonucleotide) or biological agent within 1 month of Screening or 5 half-lives of investigational agent, whichever is longer.
• Recent history of, or current drug or alcohol abuse.
• Participated in a prior donidalorsen study.
• Exposure to any of the following medications:
• Angiotensin-converting enzyme (ACE) inhibitors or any estrogen containing medications with systemic absorption.
• Oligonucleotides (including small interfering ribonucleic acid [siRNA]) within 4 months of Screening if single dose received, or within 12 months of Screening if multiple doses received. This exclusion does not apply to vaccines.

Where it is running

• Ionis Investigative Site — Paris, France
• Ionis Investigative Site — Paradise Valley, Arizona, United States
• Ionis Investigative Site — La Jolla, California, United States
• Ionis Investigative Site — Santa Monica, California, United States
• Ionis Investigative Site — Walnut Creek, California, United States
• Ionis Investigative Site — Tampa, Florida, United States
• Ionis Investigative Site — Kansas City, Kansas, United States
• Ionis Investigative Site — Boston, Massachusetts, United States
• Ionis Investigative Site — Ann Arbor, Michigan, United States
• Ionis Investigative Site — Detroit, Michigan, United States
• Ionis Investigative Site — St Louis, Missouri, United States
• Ionis Investigative Site — Mooresville, North Carolina, United States
• Ionis Investigative Site — Cincinnati, Ohio, United States
• Ionis Investigative Site — Columbus, Ohio, United States
• Ionis Investigative Site — Hershey, Pennsylvania, United States
• Ionis Investigative Site — Dallas, Texas, United States
• Ionis Investigative Site — Murray, Utah, United States
• Ionis Investigative Site — Edegem, Belgium
• Ionis Investigative Site — Sofia, Bulgaria
• Ionis Investigative Site — Sofia, Bulgaria
• Ionis Investigative Site — Ottawa, Ontario, Canada
• Ionis Investigative Site — Edmonton, Canada
• Ionis Investigative Site — La Tronche, France
• Ionis Investigative Site — Marseille, France
• Ionis Investigative Site — Berlin, Germany

Full record on ClinicalTrials.gov

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